منابع مشابه
A specific antidote for dabigatran: functional and structural characterization.
Dabigatran etexilate is a direct thrombin inhibitor and used widely as an anticoagulant for the prevention of stroke in patients with atrial fibrillation. However, anticoagulation therapy can be associated with an increased risk of bleeding. Here, we present data on the identification, humanization, and in vitro pharmacology of an antidote for dabigatran (aDabi-Fab). The X-ray crystal structure...
متن کاملThe Metamorphosis Antidote
Previews by catalyzing the removal of iodine from the inner ring. When the function of D3 was inactivated by iopanoic acid (IOPA), a specific inhibitor of the enzyme, the asym-metric growth pattern in response to thyroid hormone What if you woke up one morning and your eyes were was lost, and both dorsal and ventral CMZ grew equally. on the top of your head? You would be confused to see In comp...
متن کاملA PoTENtial Antidote
The direct oral anticoagulants (DOACs), which include dabigatran, rivaroxaban, apixaban, and edoxaban, can be given in fixed doses without routine coagulation monitoring. In clinical trials, the DOACs have been shown to be at least as effective as vitamin K antagonists (VKAs), such as warfarin, for stroke prevention in nonvalvular atrial fibrillation and for treatment of venous thromboembolism,...
متن کاملPhysostigmine as an Antidote
Introduction: Rapid treatment of patients with anticholinergic toxicity in the Ernergcncy Department (ED) has remained problematic for many years. These patients are often agitated. uncooperative, and unable to provide a clear history. Physostigmine is a specific antidote for anticholinergic toxicity. yet its popularity has waned due to controversy surrounding its potential central nervo~is sys...
متن کاملAdequacy of antidote stocking in British Columbia hospitals: the 2005 Antidote Stocking Study.
BACKGROUND Inadequate hospital stocking and the unavailability of essential antidotes is a worldwide problem with potentially disastrous repercussions for poisoned patients. Research indicates minimal progress has been made in the resolution of this issue in both urban and rural hospitals. In response to this issue the British Columbia Drug and Poison Information Centre developed provincial ant...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2015-04-636274